Project Activities &
Questions

Implement TDAs in routine care in district hospitals and primary health centres in Mozambique and Zambia, using innovative digital data collection and CDSS;
This will be done as a programmatic pilot, led by the national TB programs.

Do research and provide resulting scientific evidence on the effectiveness, the diagnostic performance, the cost and cost-effectiveness of TDAs; and identify adaptations required for specific sub-groups;
This will be done within a stepped wedge cluster-randomized trial, a meta-analysis of individual data from children with presumptive TB evaluated in recent prospective cohort studies, and economic evaluations.

Do research and provide results on the acceptability of and feasibility of TDAs by healthcare workers and implementation challenges which will be used to design tools for implementation of TDAs in contexts with different health system organisations, resources and local epidemiology;
This will be done within an interdisciplinary research programme combining qualitative and quantitative data from health care facilities, communities and decision-makers.

Build capacity and improve clinical practices of frontline HCWs for childhood TB through training, mentoring, and support supervision.

Collaborate with key stakeholders at local, national and international level, in order to ensure translation of scientific and operational evidence on TDAs into national policies and practices, scale-up plans at the national level, and international paediatric TB guidelines, and study mechanisms and determinants for policy adoption;